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Viagra®

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The Resume

    (March 27, 1998- )
    Sildenafil citrate
    Patent owned by Pfizer
    Pfizer claims hundreds worked on the development
    Invented by Pfizer employees Dr. Nicholas Terrett (circa 1958- ) and Dr. Peter Ellis
    Processed by Pfizer chemists Peter Dunn and Alfred Wood
    Dunn and Wood created a nine-step process to synthesize the Sildenafil/Viagra® compound into a pill

Why Viagra® might be annoying:

    There is no medical test for erectional disorder (impotence).
    Many men experiment with Viagra® illegally.
    The individual inventors of Viagra®, as employees of Pfizer, are not allow to comment or take individual credit for the invention of the drug.
    British newspapers credit Dr. Nicholas Terrett as the primary inventor of Viagra. He said: 'There were three patents put forward for Viagra. Basically me and my team discovered how useful the drug might be... they (Wood and Dunn) created a way of mass producing it only.'
    Joseph Moran, a car dealer from New Jersey, sued Pfizer for $110 million dollars claiming Viagra 'caused him to see blue lightning coming from his fingertips, at which point he blacked out' and crashed his car into two parked cars.
    Side effects include headache, facial flushing, and upset stomach. Less commonly, bluish vision, blurred vision, or sensitivity to light.

Why Viagra® might not be annoying:

    Pfizer employees, Andrew Bell, Dr David Brown and Dr Nicholas Terrett discovered that chemical compounds of pyrazolopyrimidinone were useful to treat heart problems such as angina (1991).
    It became available in the US in March 1998 and became the fastest selling prescription drug.
    Viagra® increases blood flow to the penis, reversing erectile dysfunctions.
    It is the first pill to treat impotence.
    Pfizer's market value doubled due to Viagra®.
    9 steps to make Viagra®
    Methylation of 3-propylpyrazole-5-carboxylic acid ethyl ester with hot dimethyl sulfate
    Hydrolysis with aqueous NaOH to free acid
    Nitration with oleum/fuming nitric acid
    Carboxamide formation with refluxing thionyl chloride/NH4OH
    Reduction of nitro group to amino
    Acylation with 2-ethoxybenzoyl chloride
    Cyclization
    Sulfonation to the chlorosulfonyl derivative
    Condensation with 1-methylpiperazine.
    Empirical formula = C22H30N6O4S
    molecular weight = 474.5
    solubility = 3.5 mg/mL in water.

Featured in the following Annoying Collections:

Year In Review:

    In 2023, Out of 9 Votes: 33.33% Annoying
    In 2022, Out of 1 Votes: 100% Annoying
    In 2021, Out of 14 Votes: 78.57% Annoying
    In 2020, Out of 2 Votes: 0% Annoying
    In 2019, Out of 3 Votes: 66.67% Annoying
    In 2018, Out of 8 Votes: 50.0% Annoying
    In 2017, Out of 7 Votes: 71.43% Annoying
    In 2016, Out of 2 Votes: 50.0% Annoying
    In 2015, Out of 11 Votes: 90.91% Annoying
    In 2014, Out of 15 Votes: 53.33% Annoying
    In 2013, Out of 10 Votes: 50.0% Annoying
    In 2012, Out of 14 Votes: 64.29% Annoying
    In 2011, Out of 20 Votes: 70.0% Annoying
    In 2010, Out of 27 Votes: 70.37% Annoying
    In 2009, Out of 42 Votes: 54.76% Annoying
    In 2008, Out of 42 Votes: 71.43% Annoying
    In 2007, Out of 106 Votes: 71.70% Annoying
    In 2006, Out of 165 Votes: 58.18% Annoying
    In 2005, Out of 266 Votes: 65.04% Annoying
    In 2004, Out of 321 Votes: 65.11% Annoying
    In 2003, Out of 657 Votes: 60.43% Annoying